![]() ![]() Thilo et al reported a 95% CI of 89% to 97%, 1 which corresponds with our findings. ![]() We found that the 5th–95th percentile ranges for preductal and postductal SpO 2 were 89%–97% for the term and NBW groups and 90%–98% for the preterm and LBW groups. 2 The mean and median SpO 2 for preterm infants were only slightly lower than those found by Ng et al, 3 Harigopal et al 4 and Richard 5 at sea level despite the early postnatal age and increased altitude in our study. This is similar to findings among well term infants in studies conducted by Thilo et al 1 and Ravert et al. We found that mean preductal and postductal SpO 2 was 93%–95% in all groups within 24 hours. The aim of this study was to establish within 24 hours the reference interval for preductal and postductal SpO 2 in healthy term and preterm neonates at 1800 m.ĭata are sparse to inform our understanding of oxygen saturation norms for newborns within the first 24 hours and for well preterm infants. 3–5 Specific gaps remain with sparse data for newborns within the first 24 hours or for well preterm infants, with no published reference ranges for preterm infants born at increased altitude. All of these studies were conducted at sea level. Ng et al 3 (N=33) found mean SpO 2 of 97% (median GA 33 weeks, median age 14 days) Harigopal et al 4 (N=43) found median SpO 2 of 95% (median GA 33 weeks, median age 14 days) and Richard et al 5 (N=55) found median SpO 2 of 99% (mean GA 35, mean age 1 day). Three studies evaluated SpO 2 in healthy preterm infants. Ravert et al 2 found mean SpO 2 of 95%–97% at ∼1371 m and 94%–95% at ∼2073 m among well term newborns during the first 72 hours. Thilo et al 1 found that mean SpO 2 was 92%–93% at 24–48 hours among well term neonates at 1610 m. ![]() Similarly, SpO 2 values may be lower at higher altitudes, such as in Kenya where 20% of the population resides above 1500 m. SpO 2 values prior to 24 hours are lower and more variable than those seen after 24 hours. It is important to define normal SpO 2 levels for neonates of different gestational ages (GA) at different time points after birth. Use of pulse oximetry relies on knowledge of normal oxygen saturation (SpO 2) values. Routine use may also aid identification of infants with clinically unrecognised respiratory abnormalities in LIC, where discharge often occurs within the first 24 hours of life. Pulse oximetry is a non-invasive method of measuring the oxygen saturation of haemoglobin, and has become a critical tool in determining need for oxygen in sick newborns. Hypoxaemia occurs in a substantial portion of hospitalised neonates, and is significantly associated with mortality. There is a large burden of neonatal mortality in low-income countries (LIC). ![]()
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